Chief Makube or Chief M'quve is Enrico Maxwell's successor as the Bureau Director of the Iscariot Organization. He is seen in the final chapter, impressed and clapping by himself, interrupting the celebration at the end of a fencing match between the then-Sir Penwood and Integra Hellsing, claiming he and the Iscariot delegation "were tired of waiting at the lobby". He is quickly sent back there by Integra, who commands him to stay there until she summons him.
He seems to be much more level-headed than Maxwell was, although he could be equally fanatical; his level-headedness (or at least a healthy self-preservation instinct) comes to surface when Heinkel Wolfe suggests a plan to kill half the Round Table, at the cost of killing both of them as well. He promptly negates permission and responds that Iscariot is willing to wait another century or two before beginning the 10th Crusade, ruminating it will be "the one they win". It could be argued that he is tolerant, unlike his predecessor.
He is definitely ordained, but it is unclear as to whether he is a priest or a bishop. He has a scar on his face, but it is unclear as to how he got it. He is shown to be perceptive of supernatural matters as he was aware that Seras' shadow, Pip, was there before being able to seemingly damage him or get him to back off.
In the Dark Horse Comics translation of Hellsing: Volume 10 in English, he is called "Chief Makube" on page 165. Since Dark Horse's English translation is widely considered to be the official translation of Hellsing, it is assumed that this is the correct English spelling of his name. Before the release of Dark Horse Comics' Volume 10, his name was often spelled M'Quive, M'Quve, or M'Qube by fans.
- Makube was based on Azaraku Makube from Susume!! Seigaku Dennō Kenkyūbu, another prototype manga created by Kouta Hirano. It's worth noting that unlike some of the other prototypes, this character's name and appearance are exactly identical to his prototype - where he had much more character development. In his prototype, Makube was a priest who also worked as a theology teacher, and was shown to use black magic and necromancy. He used a pump-action shotgun as a weapon as well.
- During the final scene of his appearance in the series, it can be seen that the glove on his right hand is very similar to the one worn by Alexander Anderson: it is inscribed "Jesus Christ is in Heaven" with a cross in the background.